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Spinosad, one of the active ingredients in Trifexis, began to kill fleas on dogs 30 minutes after administration with 100% effectiveness within 4 hours in a well-controlled laboratory study. - ; Trifexis delivers 5-in-1 protection from heartworms, fleas & 3 more intestinal parasites in dogs 5 to 10 lbs. Spinosad, one of the active ingredients in Trifexis, began to kill fleas on dogs 30 minutes after administration with 100% effectiveness within 4 hours in a well-controlled laboratory study. jcpenney maternity clothes Call us at 1-800-672-4399 Trifexis® (spinosad and milbemycin oxime) is available in five sizes for oral administration to dogs and puppies according to their weight. 5 mg/lb (30 mg/kg) and a minimum milbemycin oxime dose of 05 mg/kg). non smart tv walmart